Systemic Lupus Erythematosus General Features
Lupus Erythematosus General Features
lupus erythematosus (SLE)
is a chronic and dangerous disease with many
symptoms. SLE is an autoimmune disease in which the own immune structure is directed against the
body's own tissues. The origin of SLE is not known.
This disease is common to all ages, but is more common
in young women. The fabrication of auto antibodies
direct to immune complex formation. The immune complex
deposition in many tissues direct to the manifestations
of the disease. Immune complexes can be deposited
in glomeruli, lungs, skin, mesothelium, synovium,
and other places. Many SLE affected patients develop
healthy immune systems develop antibodies that
will help to fight and kill the bacteria as well as
viruses that affect the body. In systemic lupus erythematosus,
the body's immune system malfunctions by attacking
by itself. Rather than shielding the body from destructive
foreign substances, the immune system produces autoantibodies
plus sensitized cytotoxic T cells that injure the
host's own tissues. The immune system mistakes host
tissues for foreign ones plus increase an inappropriate
attack. These autoantibodies contribute to a multitude
of destructive effects in the body.
Relative toward the immune system, the initial obvious
abnormality of SLE is the hyperactivity of B lymphocytes.
Nor intrinsic B lymphocyte abnormalities (a subject
of current research) or else defects in assistant
T lymphocytes (CD4 cells-that regulate B lymphocyte
function) are probable contributors to the extreme
activation of B lymphocytes. The hyperactivity of
B lymphocytes consequences in the production of abnormal
antibodies, the hallmark symptom of systemic lupus
erythematosus. In SLE, abnormal B lymphocytes instinctively
secrete improved amounts of abnormal antibodies that
contribute negatively to a lacking immune system.
The production of irregular autoantibodies could also
react through a whole host of subcellular antigens.
Autoantibodies cause harm by altering the job of target
organs as well as tissues. They might also contribute
to multi-systemic swelling.